Abstract

EVALUATION OF IN VITRO ANTI-HISTAMINIC ACTIVITY OF AQUEOUS STEM EXTRACT OF BASELLA Alba ON ISOLATED CHICKEN ILEUM

Honey Haridas*, Saranya U., Ayishath Mubashira, K.K. Ayshath Mahshooma, Fathimmatu Sadiyah and Ziyad Noorudheen Ahmed

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Abstract

Medicinal plant can be defined as the plants that possess therapeutic properties or exert beneficial pharmacological effect on the human or animal body. Histamine plays a central role in the pathogenesis of several allergic diseases, such as atopic dermatitis, allergic rhinitis, and allergic asthma. The plant B.alba belongs to the family Basellaceae and commonly known as Malabar spinach, Indian spinach, Ceylon spinach and Vine spinach. Basella alba contains basellasaponins, amino acid such as arginine, leucine, isoleucine, lysine, threonine and tryptophan, peptide, phenolic compounds in various extracts. Its use has been discovered as anti-inflammatory, anti-oxidant, antiulcer activity, cytotoxic and antibacterial activity, central nervous system depressant activity, nephroprotective and wound healing properties, as asperient, rubefacient and for catarrhl infections. The present study highlights the pharmacological evaluation of in-vitro antihistaminic activity of B.alba stem by using aqueous extract which is prepared by soxhlet extraction technique. The evaluation of anti-histaminic activity is carried out in aqueous extract of stems of B.alba by using rotating drum method using chicken ileum. Antihistaminic drug are agents that are commonly used to treat symptoms of allergies. These drugs help treat conditions caused by histamine, a chemical created by your body‟s immune system. Thus, in this study the aqueous extract of B.alba shows anti-histaminic activity when compared to Ketotifen. It is found from the dose response curve of the aqueous extract of B.alba and Ketotifen.

Keywords: Anti-histaminic; Allergy; Basella alba; Aq. extract; Chicken ileum; Histamine; Ketotifen.