Abstract

A COMPARATIVE STUDY ON PHARMACEUTICAL AND PHARMACOGNOSTICAL PARAMETERS OF VARIOUS SAMPLES IN THE PROCESS OF CHATUSHASHTI PRAHARI PIPPALI PREPARATION

*Dr. Manjiri Jayprakash Walinjkar, Dr. Mandip Goyal, Dr. Harisha C. R. and Dr. V. J. Shukla

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Abstract

Background: Pippali is one of the Rasayana drugs which are indictaed in the management of the diseases of Pranavaha Srotasa. Chatushashti Prahari Pippali (CPP) is made by triturating Pippali Churna with Pippali Kwatha constantly for 64 Prahara (192 hours) which increases the potency of Pippali, making it more effective. Nowadays, due to adulteration of raw drugs or the difference in the making process, it is difficult to get the authentic and good quality CPP. Aims and objective: The five different samples of Pippali Churna in the process of making CPP were analyzed in the present study through Pharmacognostical and Pharmaceutical parameters for comparing their quality and for standardization of parameters. Material and methods: For pharmacognostical evaluation, the five samples i.e. raw drug, two market samples of CPP, self-made mid product (100 hours of trituration), and self-made final product of CPP were studied. Result: All four samples of CPP showed variation in comparison with sample one i.e. raw Pippali at various pharmacognostical and pharmaceutical parameters indicating that the process of trituration has its own unique potency modifying effect of the raw drug. Conclusion: The self-made final product of CPP is noticed as a preeminent sample for further clinical study amongst five, as stone cells, mesocarp cells were disturbed at the utmost stage in this sample releasing internal molecular contents which is an essential active component enhancing the bio-availability of the drug and thus increasing potency of the drug.

Keywords: Chatushashti Prahari Pippali, Pharmaceutics, Pharmacognosy.