Abstract

FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM

*Manisha R. Chavhan, Gajanan J. Rathod, Dr. Manisha D. Kitukale and Dr. Anil V. Chandewar

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Abstract

Oral drug delivery has been known for decades as the most widely utilized route of administration among all the routes that been employed for the systemic delivery of drug via various pharmaceutical products of different dosage forms. For sustained as well as controlled drug delivery system, the oral route of administration has received the most attention, because of ease in dosage form design for oral than parentral routes, quit high patient acceptance, relatively safe route of drug administration and minimal damage at the site of administration. An ideal or advanced drug delivery system is that, which precisely control the rate, time and site of drug delivery independently of normal physiological variables such as pH of GI tract, digestive state of GI tract, peristaltic movement and circadian rhythm.[1] An ideal dosage regimen in the drug therapy of any disease in the one which immediately attains the desired therapeutic concentration of drug in plasma and maintains it constant for entire duration of treatment .This is possible through administration of a convention dosage form in a particular dose and at a particular frequency .The frequency of administration or the dosing interval of any drug depends upon its half life or mean residence time and its therapeutic index.[2]

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