Abstract

FORMULATION AND EVALUATION OF NIOSOMES OF ACYCLOVIR

M. V. Jhansi Priya* and M. Yellappa

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Abstract

Acyclovir niosomes were prepared by thin film hydration and ether injection process with different ratios of (1:2:2, 1:4:2) drug and and Span-80, span 20(Non-ionic surfactant) cholesterol. The niosomes prepar ed were in the size range of 0.5-5 microns in the case of hand shaking process and 0.5-2.5 microns in the case of Ether inject ion process. The order of encapsulation efficiency increases when span-80 concentration was increased. In-vitro release stuy on niosomes indicates 99.15% release for formulation prepared with cholesterol: Span-80 (2:4) and it takes an extended period of 1 day and 12 h for release.

Keywords: Gene, RAPD, antioxidants, antibacterial activity, Solanum nigrum, Fusarium.