Abstract

A REVIEW ON MOUTH DISSOLVING FILMS

Vaibhav Prataprao Patange* and Prof. A. S. Pratapwar

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Abstract

The oral route is one of the most important routes for local and systemic drug delivery, because of its large surface area, high permeability, and abundant blood supply. Mouth dissolving film is the most advanced oral solid dosage form because it provides convenience and ease of use over other dosage forms such as orally disintegrating tablets, tablets and sublingual tablets, therefore mouth dissolving films are gaining popularity in the pharmaceutical industry. Fast dissolving drug delivery system were invented in late 1970s as an alternative to capsules, syrup and tablet for elderly and young patients who have difficulty swallowing conventional oral solid-dose forms. Mouth dissolving films are dissolve and disintegrate in less than a minute when placed in mouth without drinking water or chewing. This dose form allows the medication to skip first pass metabolism, potentially improving drug bio-availability. The preparation method of mouth dissolving films are solvent casting method, semisolid casting, hot melt extrusion, solid dispersion, rolling method are used. The solvent casting method is the most favoured method above others because it provides excellent thickness uniformity and produces films with a fine glossy appearance and excellent physical properties. Mouth dissolving films are evaluated for its various parameters like thickness property, folding endurance, disintegration and dissolution time. This article presents a comprehensive review of the different formulation techniques, evaluation parameters, and packaging considerations for mouth dissolving films, as well as a survey of some of the currently available commercial products in the market.

Keywords: Mouth dissolving films, Solvent casting method, Fast disintegration, Pediatric patients, Bio-availability.