Abstract

PHARMACO-ANALYTICAL STUDY OF TRAYODASHANGA GUGGULU VATI

Sreekala A. P.*, Anup B. Thakar, Harisha C. R. and Shukla V. J.

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Abstract

Trayodashanga Guggulu is an Ayurvedic herbo-mineral formulation found to be very effective in Vatakapha condtions especially vata vyadhi. It is indicated in nervous disorders and musculoskeltal disorders. The overall aim of drug standardization is to ensure the quality, efficacy and uniformity of the products, in terms of their chemical and biological properties, across the manufactures and it should be started with the identification and authentication of the drug. Materials and Method: Pharmacognostical evaluation carried out at Pharmacognosy department, ITRA, Jamnagar, pharmaceutical and HPTLC study were done at Pharmaceutical chemistry department, ITRA, Jamnagar. Microbiological evaluation was carried out at department of Microbiology I.T.R.A, Jamnagar. Results: Organoleptic examination: Colour: Blackish, Odour: Ghee odour, Taste: Astringent, bitter, Touch: Hard Pharmaceutical evaluation: Loss on drying: 7.75% Ash Value: 13.25% Weight variation (Average weight):498.1mg, Water solubility: 25.26% Alcohol solubility: 17.6% Hardness of Vati (Average): 2.16kg/cm2pH: 6.5. The HPTLC of TG, 6 major spots were observed at 254nm (short wave) showed mainly 7 major spot and at 366 nm (long wave) showed 5 major spots. No organisms isolated in aerobic and fungal culture, in microbiology evaluation. Conclusion: quality control parameters were followed during the collection, identification, preparation and packing of the sample. HPTLC evaluation confirmed the authenticity of the sample. Absence of contamination is confirmed by the microbiological investigation.

Keywords: Pharmaceutical analysis of Trayodashanga Guggulu, Analysis of Vati, Standardization of Vati, Pharmacognosy of Trayodashanga Guggulu.