Abstract

PHYTOCHEMICAL SCREENING AND ANTI-ARTHRITIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF VERBASCUM THAPSUS

Rajni Rathore*, Sujata Kushwaha, Narendra Patel and C. K. Tyagi

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Abstract

Rheumatoid arthritis is a major auto immune disorder of body and affects the various joints which may lead to physical disability. The leaves of Verbascum Thapsus has long been used traditionally to treat rheumatoid arthritis. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study phytochemical analysis of hydroalcoholic extract of Verbascum Thapsus leaves. Antiarthritic potential was evaluated through Complete Freund’s Adjuvant induced arthritis rats model at 250 mg/kg/p.o doses of the Hydroethanolic extracts of Verbascum Thapsus leaves using Diclofenac sodium as a standard drug. Apart from this we have evaluated paw edema parameters. The results revealed various arthritic protective mechanisms. Similarly plant exhibited dose dependent anti-arthritic effect with maximum activity observed at 500 mg/kg/ p.o. The results of Complete Freund’s Adjuvant (CFA) model depicted better protection against paw edema and body weight alterations. Also Verbascum Thapsus leaves extracts remarkably altered locomotion of rats, and positive results were seen in hematological parameters and radiography. Moreover phytochemical analysis revealed phenols and flavanoids. By deeply analyzing the obtained results and data our research work supports the traditional use of Verbascum Thapsus leaves as a potential anti arthritic agent that may be proposed for rheumatoid arthritis treatment.

Keywords: Rheumatoid arthritis, Complete freund’s adjuvant, Verbascum Thapsus, Diclofenac sodium, Flavanoids.