Abstract

NANOEMULGEL: A NOVEL EMERGING TOOL

Nachiket M. Bhave*, Divya G. Shinde, Prashant B. Patil and R. S. Bachhav

.

Abstract

Most recently produced medications lipophilic nature has led to low bioavailability and pharmacokinetic variability. The objective of this study is to assess and discuss the existing potential and future potential of nanoemulgel formulation as a useful delivery strategy for pharmaceuticals that are poorly water-soluble. There are two alternative ways to insert a drug-containing nanoemulsion into a gel base in a nanoemulgel. This formulation has various benefits as a result of the combination of these two systems. Due to the finely dispersed oil droplets in the gel phase, lipophilic medicines can be easily integrated and their skin permeability can be multiplied. Additionally, it can prevent first pass metabolism, target the site of action more precisely, and alleviate the user of gastric/systemic incompatibilities. A formulation-related intervention to enhance drug absorption and the therapeutic profile of lipophilic medicines is the nanoemulgel drug delivery system. The usage of nanoemulgels has been on the rise recently due to their improved patient acceptability due to their non-greasy, convenient spreadability, facile applicability, and good therapeutic and safety profile. Nanoemulgel formulation might be thought of as prospective and promising candidates for topical distribution of lipophilic medications in the future, albeit having few restrictions.

Keywords: Nanoemulgel, Lipophilic, Homogenization, Spreadability, Skin Permeation.