Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF BUCLIZINE DIHYDROCHLORIDE

Krishna Rajesh Chhoda* and Sagar Suresh Jadkar

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Abstract

The pharmaceutical industry has greatly benefited from transdermal medication administration. It is a patch that releases a specified dosage of medicine into the bloodstream through the skin. The fundamental benefit of transdermal medication administration is that it bypasses the gastrointestinal tract and the liver's first-pass effect. This allows drugs to be delivered directly into the systemic circulation. One benefit of transdermal drug administration over other methods is that the patch permits a controlled flow of the medication into the patient, often through a porous membrane that covers or melts a drug reservoir. Body heat is used to embed thin layers of medication in a binder. Using the solvent evaporation method, the current study aimed to create buclizine dihydrochloride transdermal films and assess physicochemical factors like thickness, weight change, moisture absorption, moisture content, folding strength, and drug content value. Five transdermal patches were created utilising various methyl cellulose concentrations. It was determined that the patch's thickness, weight homogeneity, and folding strength all rose as the polymer concentration did. With increasing polymer concentration, both the amount of moisture and the percentage of moisture absorption decreased.

Keywords: Transdermal Patches, Skin, Buclizine Dihydrochloride, Ethyl cellulose.