Abstract

TOXIC AND BIOLOGICAL EFFECTS OF GLYPHOSATE IN ANIMALS

Archana Rao, Sunil Kumar Srivastav and Ravi Kant Upadhyay*

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Abstract

In present review article hazardous and biological consequences of glyphosate herbicide have been discussed in detail. For the suppression of grass, sedge, and broadleaved plants, this is a systemic, nonselective herbicide that is often used in agriculture. Its commercial formulations are offered on the market under a variety of brand names. It affects the function of the kidneys, liver, colon, small intestine, bone, and bone marrow badly after entering the body by the skin, mouth, and inhalation. Following distribution, waste is eliminated by faeces and urine. It damages the hepatorenal system in farmers and has detrimental health implications, such as an increased risk of cancer. This endocrine disruptor may have an impact on reproductive processes. Additionally, it has a negative impact on thyroid and adrenal gland function. The concentrations of luteinizing hormone, prolactin, oestrogen, progesterone, and the testosterone/oestrogen ratio dramatically rose whereas the levels of testosterone and folliclestimulating hormone significantly dropped in glyphosate-treated rats. Additionally, it displays the onset of behavioural and motor abnormalities as well as neurotoxic consequences like as necrosis or apoptosis. Additionally, it has cytotoxic and genotoxic effects, increases oxidative stress, changes the oestrogen system, impairs a variety of mental abilities, and could be related to some cancers.

Keywords: Herbicides, glyphosate, endocrine disruptor, cytotoxic, xenotoxic effects, hepatotoxic and renal endocrine inhibitor.