Abstract

FRUIT EXTRACT IN COMBINATION WITH NON-STEROIDAL ANTIINFLAMMATORY DRUGS TO PREVENT HEPATIC DAMAGE: A POTENTIAL FORMULATION FOR FUTURE

Shakir*, Km Kahkasha, Danish Saifi and Aamir

.

Abstract

So many statements and research data are mentioned the hepatotoxicity of the Non-steroidal anti-inflammatory (NSAIDs) as a major side effects. Among all other Naproxen sodium is still prescribed and utilized for severe pain. Functionally it is a non-specific inhibitor of the COX-1 and COX-2 and diminishes the action of prostaglandins in human as well as rodents. Side effects with the use of Naproxen sodium are not limited to vomiting, it initiate discombobulating dyspepsia and finally and majorly does liver injury likewise naproxen sodium have negative impact on digestive system, hypersensitivity and ultimately does production of reactive oxygen species which further burden the human as well animals in the form of oxidative stress. Various researcher tried in past to overcome the side effect of naproxen sodium by employing pharmaceutical technologies but still some lacking in positive results. In spite of that, many herbal plant secondary metabolites which have known anticipatory impact on oxidative stress caused by naproxen sodium are utilized to overcome its negative impact but the herbal toxicity is again considerable and questionable status in terms of utilization of herbal plant secondary metabolites in combination with naproxen sodium. Over the counter, the fruits extracts that have good ant oxidative profile are utilized in combination with naproxen sodium in various animal as well as human studies. Competitively fruits are finds a safer place in terms of toxicity like herbal plant extracts. Now, the new studies with formulation development in combination of fruit extract are warranting to overcoming the hepatic side effects of naproxen sodium.

Keywords: Naproxen sodium, fruit extract, Hepatotoxicity, Antioxidant activity; Antimicrobial and antiviral effect; Anti carcinogenic activity; Hepatoprotective activity.