Abstract

RECENT DEVELOPMENTS IN DENT INFORMATICS: ROLE OF BIOINFORMATICS

Chandni Verma, Shaista Suhail, O.P. Gupta, Shalini Gupta*

Abstract

Dental informatics/dent informatics is the sub-disciplinary shoot of biomedical informatics. Bioinformatics is a relatively interdisciplinary field of life sciences. Successful completion of the Human Genome Project it became in the frame, bioinformatics made it easy to organize and access the exponentially generated large data. One discipline of the dentistry is benefitted by the bioinformatics is oral pathology. Data mining techniques and its implementation in the disease diagnosis, micro array analysis technique, genomic and proteomics used as a tool in detection of oral precancerous stages to malignant stage are discussed in this review article. Genomics belongs to the study of genome of the organisms; microarray technique is helpful in detection of genetic alteration in the oral cancer. Besides this, proteomics provides the information of total protein profiles of a cell. Proteomics allows the detection of many diseases or causative pathogens of head and neck region. Oral cancer related databases are helpful to access all the information of oral cancer related gene, carcinogens, gene function, cell signaling, pathway and mechanism. Here, in this review article attempts the computational applications which are beneficial in the development of the dent informatics, specialty and its application in oral pathology.

Keywords: dent informatics, bioinformatics, genomics and proteomics, microarray, data mining technique.