Abstract

COMPARATIVE STUDIES OF DIFFERENT MARKETED BRANDS OF PARACETAMOL

Krishna K. R.*, Chaithanya M., Preethi B. H. and Vaishali K.

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Abstract

The study objective is to contrast and assess several 500mg Paracetamol tablet brands. In this study, we choose four brands of 500mg Paracetamol tablet from the local market and evaluate them for weight variation, hardness, friability, disintegration, and dissolution test, among other quality control measures. The weight variation for all four brands of Paracetamol tablet is within ±5% of their average weight, and friability is not more than 1%. All paracetamol tablets disintegrate within 15 minutes, and the maximum percentage limit for all brands of Paracetamol tablets was discovered to be not less than 85% according to IP specifications limit within 30 minutes. We therefore came to the conclusion that all Paracetamol tablets from various manufacturers are safe and useful to use, with the exception of the cost. Although brand specific variations in physio-chemical tests such as weight variation, friability, disintegration, dissolution, and assay were observed, these tests were determined to be adequate to set limits. Despite being an over-the-counter medication, too much paracetamol is being used. The authenticity, quality, and marketing of each brand are so crucial. Therefore, further investigation into the quality of paracetamol is necessary to ensure its safety for human ingestion.

Keywords: Different brands of paracetamol, Analgesics, Antipyretics, Comparative Analysis, Quality control test.