Abstract

DESIGN, SYNTHESIS, AND EVALUATION OF NOVEL PYRAZOLE DERIVATIVES AS POTENTIAL ANTI-INFLAMMATORY AGENTS

Sandeep Patil*, Ramesh Hedgapure and Parvathi C. V.

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Abstract

The objective of this research is to develop new substituted pyrazole derivatives with potential anti-inflammatory properties. Many presentday diseases result from infections by pathogenic microorganisms, such as fungi, bacteria, viruses, and rickettsiae. To combat these diseases, potent and broad-spectrum antibiotics have been discovered. Inflammation is a complex process involving various vasoactive, chemostatic, and proliferative agents. Anti-inflammatory drugs primarily work by inhibiting prostaglandin (PG) synthesis at the site of injury. The effectiveness of anti-inflammatory compounds is often correlated with their ability to inhibit cyclooxygenase (COX), a key enzyme in PG synthesis. This study focuses on the synthesis of substituted pyrazoles, which have gained attention due to their diverse biological activities and therapeutic potential. A literature survey highlights the antiinflammatory properties of substituted pyrazole derivatives. The methodology involves multistep reactions to synthesize these compounds and characterizing them using various physical and spectral data, including melting points, IR spectra, proton NMR, and mass spectrometry. These newly synthesized pyrazole derivatives hold promise for contributing to the development of novel anti-inflammatory drugs and expanding our understanding of their therapeutic potential.

Keywords: melting points, IR spectra, proton NMR.