Abstract

INVESTIGATION OF ANTI-ARTHRITIC EFFECT OF MICHELIA CHAMPACA LINN LEAVES

J. Priyananga*

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Abstract

The Michelia champaca tree is a large, attractive, evergreen tree that may grow up to 30 meters tall. It contains 220 species, 12 genera, and fragrant golden yellow flowers and aggregate fruits. Using a Soxhlet system, the powdered leaves of Michelia Champaca was extracted using a 70% ethanol solvent. The dried extract was named as EEMC. The anti-arthritic activity of Indomethacin was shown to be significant in the current investigation. At high doses, the EEMC significantly reduced serum SGOT and SGPT levels, while ALP did not affect hematological parameters like WBC and ESR and increased levels of RBC and Hb% in rats with CFA-induced arthritis models. Studies on radiography and histology showed that a high dose of the extract in CFA-induced arthritis was close to the normal structure of the knee and paw joints, respectively. Several phytochemical components found in EEMC, including flavonoids, saponins, fixed oils, glycosides, and alkaloids, have previously been linked to anti-arthritic effects. Therefore, the reported anti-arthritic effects can be explained by these chemical components.

Keywords: Michelia champaca, Anti-arthritic, Soxhlet apparatus, 70% ethanol.