Abstract

EFFECT OF PROPHYLACTIC INTRAVENOUS ONDANSETRON ON SPINAL ANESTHESIA INDUCED HYPOTENSION AND BRADYCARDIA IN TERTIARY CARE CENTRE - A RANDOMISED CONTROLLED TRIAL

Rakshith N., Hema N. G.* and Shalini A.

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Abstract

Background: Spinal anaesthesia is a safe anesthetic technique commonly practiced. Hypotension and bradycardia are the common side effects seen after spinal anesthesia, which are induced by hypovolemia, sympathetic blockade, bejold-jarisch reflex through intra cardiac serotonin receptors and vagus nerve. Multiple strategies are tested to prevent the post spinal anesthesia induced hypotension, Recently, ondansetron, a 5HT3 antagonist commonly used as an antiemetic, found to be effective in preventing spinal anesthesia induced hypotension. Aim: To assess and compare haemodynamic parameters between study and control group. To study the effect of prophylactic intravenous administration of ondansetron on hypotension and bradycardia. Methodology: This is a prospective randomized placebo controlled trial done in tertiary care teaching hospital. Ondansetron, Hypotension, Bradycardia, Spinal Anesthesia, Bezold-Jarish reflex. Of 120 patients, 60 were in Group A and 60 were in Group B. Patients in Group A (ondansetron group) were given 4mg ondansetron diluted in 5ml normal saline, patients in Group B (control group) received 5ml normal saline 5mins prior to spinal anesthesia which is 15mg of 0.5% hyperbaric bupivacaine, injected intrathecally. Mean arterial pressure and heart rate were recorded every minute upto first 5 mins, every 3mins in next 15 minutes and every 5 mins till the end of the procedure. If SBP dropped

Keywords: Ondansetron, Hypotension, Bradycardia, Spinal Anesthesia, Bezold-Jarish reflex.