Abstract

FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLET OF NEVIRAPINE BY MELT SONO CRYSTALIZATION TECHNIQUE

Sayyed Khaled*, Adnan Siddiqui, Shaikh Aaqueeb, Bagwan Wasim, Rehan

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Abstract

Oral drug delivery is the most preferred route of drug delivery of pharmaceuticals and convenient option as the oral route provides maximum active surface area among all drug delivery system for administration of various drugs. A revolutionary particle manufacturing process called melt sonocrystallization involves applying ultrasonic (Ultrasonic) energy to a soft or viscous molten mass that is spread in an immiscible liquid. Fast-disintegrating tablet of Nevirapine were prepared by direct compression method using different concentration of superdisintegrant. The prepared fastdisintegrating tablet of Nevirapine were evaluated for hardness, thickness, weight variation, friability, disintegration time, wetting time and In-vitro release study and the results found to be satisfactory. Batch no F9 were selected as optimized formulation and it was subjected to kinetic study and it was appeared to occur in the pattern case II transport. Optimized formulation was then subjected to stability studies for 3 months with at specific temperature and relative humidity.

Keywords: Nevirapine, Drug delivery, Ultrasonic, Melt sonocrystallization, Crospovidone.