Abstract

FACILE SYNTHESIS OF PHARMACEUTICALLY 1,3,4- THIADIAZOLES FROM ACYL HYDRAZIDES AND NITROALKANES WITH ELEMENTAL SULFUR

Khalil Ullah*, Muhammad Irfan, Muhammad Hashim Khan, Muhammad Waleed Ahmad

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Abstract

Due to their widespread use as antifungal, anti-inflammatory, antimicrobial, antiviral, and anticancer medicines, 1, 3, 4-Thiadizoles will prominent groups of organic heterocyclic composites with considerable biological properties. Innovative 1, 3, 4-thiadizole medication attributes will constantly attracting the attention of researchers. Even though there has been a lot of study on thiadizoles, attempts will currently be made to find new heterocyclic compounds with powerful biological activity. Our research's primary objective is to design effective coupling methods for the synthesis of novel 1, 3, 4- thiadizole members that may possess medicinal potential. The synthesized compounds will then have subjected towards column chromatography for purification, and their automated assets will be examined by DFT simulations. The structural chemical individualities of the synthesized composites will be identified via characterization approaches (NMR, FTIR, and Uv-Visible analysis).

Keywords: Pharmaceutically 1, 3, 4-Thiadiazoles, Acyl Hydrazides, Nitroalkanes, Elemental Sulfur”.