Abstract

A PHARMACEUTICO-ANALYTICAL AND ANTIMICROBIAL STUDY OF SAPTAPARNA KSHARA W.S.R TO SUSHRUTA SAMHITA

K. S. Sindhura*, K. G. Purushotham, M. Harshitha and Gopalakrishna N. Nayak

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Abstract

Acharya Sushruta has explained the preparation of Saptaparna Kshara in Sutra Sthana, Ksharapakavidhi Adhyaya. It is indicated in Vrana, Vatakaphaja Roga, Kusta, Raktavikara, Krimi, Shwasa and Gulma. The method of preparation varies from other classics on the basis of ratio of water and ash, duration of soaking and filtration pattern. As Kshara is indicated in Krimi Roga, the present study is also taken up to evaluate the antimicrobial activity of Saptaparna Kshara on the microbes causing diseases of gastrointestinal tract viz, Escherichia coli, Salmonella typhimurium and Candida albicans. Pharmaceutical, Analytical and Antimicrobial study was conducted with Saptaparna Kshara. Saptaparna Kshara preparation was carried out by classical method described in Sushruta Samhita.[1] Acharya Sushruta explains about ratio of ash and water as 1:6, filter 21 times through single folded cloth. Organoleptic, Physico-chemical and Chromatographic analysis were carried out for Saptaparna Kshara preparation. Antimicrobial study was conducted against Escherichia coli, Salmonella typhimurium and Candida albicans. Organoleptically the sample Saptaparna Kshara had grey colour and characteristic odour of Kshara. The quantitative analysis reveals that the drug has presence of elements like Sodium, Potassium, Calcium, Magnesium. TLC of the sample shows around 2 prominent Rf values with almost same colour bands with similar Rf values. Antimicrobial study of Sample Saptaparna Kshara showed antibacterial and antifungal actions against Escherichia coli, Salmonella typhimurium, Candida Albicans.

Keywords: Saptaparna, Kshara, Krimi, Escherichia coli, Salmonella typhimurium, Candida Albicans.