Abstract

DESIGN AND INVITRO CHARACTERIZATION OF BUCCOADHESIVE DRUG DELIVERY SYSTEM: NEFOPAM HYDROCHLORIDE

Sunil Firangi*, Khan Sana Niyaz Ahmed, R. B. Sangoligi and Dr. Syed Sanaullah

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Abstract

Nefopam is effective for prevention of shivering during surgery or recovery from surgery, significantly more effective than aspirin as an analgesic with a greater incidence of side effects such as sweating, dizziness and nausea, especially at higher doses. The buccal region, mucosal cavity of the mouth provides an alternative route over an oral drug administration for systemic as well as local drug delivery. The aim of the present study was to develop buccal tablet of Nefopam HCl to maintain constant therapeutic levels of the drug for over 10 hrs. Various grades of HPMC were employed as polymers. Nefopam HCl dose was fixed as 120 mg. Total weight of the tablet was considered as 500 mg. Polymers were used in the concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e., 98.56% in 10 hours. It followed zero order release kinetics mechanism. As the buccal mucosa has an abundant blood supply and is relatively permeable, it can be considered as most accessible and desired location for both local and systemic drug delivery for the buccal cavity or bucco-adhesive systems.

Keywords: Nefopam HCl, HPMC, Buccal Tablets, bucco-adhesive systems.