Abstract

H. PYLORI INFECTION ACCORDING TO ABO PHENOTYPE AND RH FACTOR AMONG IRAQI PATIENTS WITH PUD

Rana H. Kutaif*, Yassir M. Kamal Al Mulla Hummadi and Akram A. Najeeb

Abstract

The correlation between Helicobacter pylori (H. pylori) infection and ABO phenotypes have been widely evaluated in peptic ulcer disease in the past. But data concerning the same evaluation are very limited in Iraq. The aim of this study was to determine the relationship between ABO blood groups and Rh factor and H. pylori in patients with peptic ulcer disease in Iraq. A prospective case controlled study was carried on 112 patients (45 female and 67 male; age range 15-77 years) who had peptic ulcer disease, 84 patients were positive for H. pylori infection confirmed by (histology and stool antigen test) while 28 patients were negative for H. pylori. Blood samples were used for ABO phenotyping and Rh factor. Biopsy for histopathology was taken from all patients. The results showed that patients with blood groups O were more prone to H. pylori infection than patients with other blood groups with high significant difference (p< 0.01), while patients with blood groups A had lower rate of infection compared to other blood groups with high significant difference (p< 0.01). The percentage of H. pylori positive in peptic ulcer disease patients was (96.43%) versus (3.57%) in Rh (+) and Rh (-) respectively. whereas the percentage of H. pylori negative was (92.86%) versus (7.14%) in Rh (+) and Rh (-) respectively without statistical difference (P>0.05). Males are more prone to H. pylori infection in all blood groups than females with highly significant (P< 0.01). On conclusion; the results of this study demonstrate that H. pylori infection can be related to ABO blood group in peptic ulcer disease patients. People of blood group O are more prone to develop infection related ulcer. Male are more susceptible to infection than female in different ABO phenotypes.

Keywords: H. pylori; peptic ulcer disease; duodenal ulcer; gastric ulcer; ABO blood groups; ABO phenotype; Rh factor.