Abstract

CYTOKINES REGRESSION ACCORDING TO AGE OF HAEMODIALYSIS OF IRAQI PATIENTS DURING MAINTENANCE

*Mohemid M AL-Jebouri and Huda R Al-alwani

Abstract

Background: Chronic inflammation is a common feature of end stage renal disease which carries a heightened risk of atherosclerosis and other co-morbid conditions. Dialysis treatment might associated with flacuation in levels of interleukins of serum patients. The present study was designed to determine the level of proinflammatory cytokines in chronic renal failure and whether a haemodialysis session leads to an acute substantial alteration in the plasma levels of the proinflammatory interleukins IL-6, IL-1β and tumor necrosis factor TNF-α with reference to age. Methods: To determine the plasma level of IL-6, TNF-α, and IL-1β, 100 patients with ESRD were studied as described elsewhere.[1] Patients aged between 18 to 80 years. Results: Using the linear regression analysis, it was found that the IL-6 level was decreased with increase the dialysis age (P value < 0.05), and the regression pattern of IL-6 with dialysis age was differ from TNF-α and IL-1β.This was observed in the different values of coefficient determination (R2) factors. Conclusions: IL-6 revealed the highest value R2= (0.418) followed by TNF-α which showed R2 value (0.225), while IL-1β with R2 factor = 0.099.

Keywords: Heamodialysis age, Cytokines regression, Iraqi patients.