Abstract

TOTAL FLAVONOID CONTENT AND ANTI-INFLAMMATORY PROPERTIES OF INDONESIAN MISTLETOES (DENDROPHTHOE PENTANDRA (L.) MIQ.) ETHANOL EXTRACT

Resmi Mustarichie*, Sohadi Warya, Nyi Mekar Saptarini and Danni Ramdhani

Abstract

Traditionally mistletoes Dendrophthoe pentandra (L.) Miq known in Indonesia is used to cure cough, hypertension, diabetes, cancer, ulcers, smallpox, diuretic, skin infection and after child-birth. The result of its phytochemical screening of the n-hexane fraction showed the presence of flavonoids, monoterpenes, and sesquiterpenes, acid ethyl acetate fraction showed the presence of flavonoids, and Quinones, alkaline ethyl acetate fraction showed the presence of flavonoids, polyphenols, tannins, and Quinones, while the water fraction showed the presence of flavonoids, polyphenols, tannins, and Quinones. Calculated the total flavonoid as quercetin showed that levels of total flavonoids of 0.068 kg w/w. Anti-inflammatory activity of the fraction of n-hexane, ethyl acetate acid, ethyl acetate base, and water from mistletoes Dendrophthoe pentandra (L.) Miq were conducted against white male Wistar rats. Tests Carried out using the method inducers of carrageenan in the rat right foot. The test material was administered at a dose orally of 1000 mg/kg BW. For comparison used indomethacin 10 mg/kg BWbw, and used as a control PGA 2%. Anti-inflammatory activity was observed for 5 hours after carrageenan inducers. The test results Showed that the ethyl acetate fraction of acid at a dose of 2000 mg/kg bw have the best activity. At this dose acid ethyl acetate fraction Showed the percentage of 41.46% inhibition of inflammation. Anti-inflammatory was thought to be the caused by the flavonoids contained as quercetin. The results of this study are supporting data of the Dendrophthoe petandra that can be used as an adjuvant treatment in anti-inflammation caused by the breast cancer.

Keywords: mistletoes Dendrophthoe pentandra, phytochemical screening, total flavonoids, anti-inflammation.