Abstract

NASAL DRUG DELIVERY SYSTEM AN OVERVIEW

Pawar Piyush Nandkumar*, Shinkar Dattatraya Manohar, Saudagar Ravindra Bhanudas

Abstract

Drug delivery through nasal route has attracted the interest of scientific community as it has been potentially explored as an alternative route for the administration of vaccines and bio molecules such as proteins, peptides and non-peptide drugs that are susceptible to enzymatic or acidic degradation and first-pass hepatic metabolism. Nasal route is beneficial for the drugs which are unstable on oral administration because they are significantly degraded in GIT or metabolized by first pass effect in liver. In addition it minimizes the lag time associated with oral drug delivery and offers noninvasiveness, self medication, patient comfort and patient compliance which are hurdled in intravenous drug therapy. In this article an overview of intranasal drug delivery with its various aspects like factors affecting nasal absorption, strategies to improve bioavailability are discussed.

Keywords: Intranasal drug delivery, Bioavailability, Permeation enhancers