Abstract

A COMPREHENSIVE STUDY THE DEVELOPMENT AND EVALUATION OF ANTIFUNGAL CREAM USING BUTEIN

Shrikant Sahu*, Dr. Ananad Mahalwar, Ashwanee Kumar Sahu, Yugal Kishor Rajput, Rajendra Kumar Sahu

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Abstract

The treatment of fungal infections, ranging from superficial skin conditions to severe systemic diseases, remains a significant challenge in modern medicine. Antifungal creams have gained prominence as localized treatment options, offering targeted therapy and minimizing systemic effects. However, the emergence of antifungal resistance and limitations of current treatments necessitate the exploration of innovative alternatives. This study introduces butein, a natural polyphenolic compound, as a potential game-changer in the realm of antifungal therapy. The research aims to develop, evaluate, and elucidate the antifungal efficacy of a butein-infused antifungal cream, addressing the critical need for effective fungal infection management. The introductory section begins by shedding light on the vital role of antifungal creams in addressing fungal infections of the skin, nails, and mucous membranes. Their local application, minimal systemic absorption, and convenience are highlighted as key advantages. Within this context, the introduction of butein as a promising antifungal agent is presented. Derived from diverse plant sources, butein has gained attention for its multifaceted biological activities, including antifungal potential. This study sets its sights on harnessing these properties to develop a topical antifungal cream. The central research objective is stated clearly: to formulate and thoroughly evaluate an antifungal cream enriched with butein. The multifaceted nature of this objective is underpinned by a comprehensive methodology that spans various domains. The literature review section delves into the prevalence and types of fungal infections, emphasizing the need for effective antifungal interventions. A review of existing antifungal agents and their limitations underscores the urgency of exploring alternative treatments. The introduction of butein as a potential solution is substantiated by its natural origins and documented pharmacological properties. Existing studies documenting butein's antifungal activity are presented as a foundation for the current research. The methodology section commences by elucidating the extraction and purification processes employed to obtain high-quality butein from natural sources. The meticulous formulation development process is detailed, encompassing the selection of cream base, emulsifiers, stabilizers, and other excipients. The rationale behind incorporating butein into the cream is expounded, drawing from its demonstrated antifungal potential. To ensure the cream's quality and efficacy, its physical properties are characterized through various tests, with a focus on proper butein dispersion and stability. The subsequent sections explore the antifungal cream's potential through in vitro and in vivo evaluations. In vitro antifungal activity is assessed using a range of fungal strains, with methodologies such as determining minimum inhibitory concentrations and zones of inhibition providing insights into the cream's efficacy. The results are compared with standard antifungal agents, shedding light on the cream's comparative advantage. In vivo evaluation, if applicable, is conducted within a framework of ethical considerations and protocol adherence. The efficacy and safety of the buteincontaining cream in treating fungal infections are presented, further establishing its potential. The cream's stability and shelf life are assessed through meticulous stability studies, ensuring its long-term viability. Exploring the mechanism of action, the study delves into potential interactions between butein and fungal cells, offering insights into its antifungal effects. The conclusion and future directions section summarizes the study's findings, highlighting the successful development and evaluation of the antifungal cream containing butein. The implications of the research in the context of future research and clinical applications are discussed. Potential areas of improvement and further investigation are underscored, setting the stage for continued advancements in antifungal therapy.

Keywords: Fungal, Antifungal, Cream, Stability, Butein, Research, Comprehensive, Methodology, Cells, emulsifiers, stabilizers, etc.