Abstract

FORMULATION AND EVALUATION OF LEVODROPROPIZINE LOZENGES

Srikanth Parepalli, Madhusudan Rao Y* and Shravan Kumar. Y

Abstract

In the present investigation Levodropropizine was formulated as high boiled sugar hard candies to provide slow release of medicament for the treatment of bronchial cancer induced cough and cough due to other reasons. The local acting mechanism of levodropropizine makes it more suitable to formulate as lozenges. . The hard candy lozenges were formulated using sugar as a base and the usage of corn syrup in the formulation made the lozenges transparent and smooth which helped in improving the elegancy of formulation. Formulations of hard candies were subjected to physico-chemical as well as in-vitro drug release. Among all the formulation of among all the formulation of hard candy lozenges FL13, FL14 and FT15 had shown in-vitro drug release of 99.1%, 98.2% and 95.5% at the end of 20 min.

Keywords: Hard candy lozenges; corn syrup; transparent; cough.