Abstract

DEVELOPMENT AND IN VITRO EVALUATION OF PERINDOPRIL FLOATING TABLETS

Srinivas Martha*

Abstract

The purpose of this research was to develop a novel gastro retentive floating tablets of Perindopril. Perindopril has half life (1-17 hrs) so an attempt has been made to Sustain the drug release by the incorporation of hydrophilic swellable polymer such as Hydroxy propyl methylcellulose and present it in the form of gastro retentive floating tablets, which after oral administration are designed to provide the desired controlled and complete release of drug for prolonged period of time in the treatment of high blood pressure. Floating effervescent tablets were formulated by using various materials like Hydroxy propyl methylcellulose, xanthan gum, and gas generating agents like sodium bicarbonate. The concentration of these agents was also optimized to get desired controlled release of drug. The floating tablet formulations were evaluated for physical characterization, hardness, friability, weight variation, drug content uniformity, swelling index and buoyancy studies. The results indicated that the floating tablets formulation (F4) prepared by direct compression with Drug: Xanthan gum (40%) at a ratio of 1: 8 could be suitable for extending the drug release up to 12 hrs. In-vitro drug release kinetics evaluated using the linear regression method was found to follow the Higuchi followed by Korsemeyer and Peppas equation.

Keywords: Perindopril, gastro retentive, intragastric floating tablets, buoyancy, Floating drug delivery, controlled release.