Abstract

TERATOGENIC EFFECT OF SWASA-KASA-CHINTAMANI-RASA (SKCR) IN ANIMAL MODEL

*Vaibhav Jaisawal, S. N. Shamal and 3B.M. Singh

Abstract

The drug Swasa-Kasa Chintamani Rasa, a herbometallic drug is commonly used for the treatment of bronchial asthma in the children. This study was designed to evaluate its teratogenic effect, if any, on the fetuses of pregnant mice. The healthy mice of 120 days old 10 male and 10 female of Swiss strain were selected with an average weight 25 grams. The drug in a dose of 16mg/kg/day was given orally from 5th day to 9th day of gestation once in a day for 5 consecutive days to mice of group-A, while the mice in Group „B‟ were given only distill water of same dose. On Day 18thFetuses were collected after scarifying the pregnant mice. Mean weight and length of fetuses of group A were observed significantly reduced than group B fetuses. Histological findings of treated groups have shown reduction in neuronal population, edema, scanty Kuffer cells, degeneration and apoptosis etc. in the tissues. Hence these findings suggest that Swasa-Kasa-Chintamani-Rasa [SKCR] produces embryo toxic effect on the developing mice.

Keywords: SKCR, embryotoxic.