Abstract

ANTIARTHRITIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF LEAVES OF AMARANTHUS TRICOLOR IN FREUND’S COMPLETE ADJUVANT- INDUCED ARTHRITIS IN WISTAR RATS

Gopal V. Bihani*, Parag P. Kadam, Subhash L. Bodhankar

Abstract

The objective of the study was to evaluate antiarthritic activity of hydroalcoholic extract of Amaranthus tricolor L. (HAEAT) in Freund’s complete adjuvant (FCA) induced arthritis in female Wistar rats. HAEAT was prepared by maceration and subjected to preliminary phytochemical screening and tested against FCA induced arthritis in rats. Arthritis assessment was done by measuring- paw volume, joint diameter, body weight, arthritis score, pain threshold, thermal hyperalgesia, haematological and biochemical parameters. The HAEAT was administered at the concentrations of 100, 200 and 400 mg/kg body weight. HAEAT (200 and 400 mg/kg) significantly (p

Keywords: Amaranthus tricolor L, Rheumatoid arthritis, Freund’s complete adjuvant, Antiarthritic.