Abstract

AN EXPERIMENTAL STUDY TO ASSESS THE EFFICACY OF BIODEGRADABLE PATCH IMPREGNATED WITH COMPOUND AYURVEDIC DRUG IN EXCISIONAL WOUND MODEL OF ALBINO RAT

Awadhesh Kumar Pandey*, PathakMeenakshiS.N., Prof.M.Sahu, Dr.Vijay Kumar

Abstract

The aim of this study is to assess the wound healing activity of Biodegradable patch on excisional wound model in Albino Rat. Bio degradable patches were prepared by using the Compound ayurvedic drugs consisting of aqueous extracts of stem bark of four Ficus species i.e Vata (Ficus bengalensis Linn.),Ashwatha (Ficus religiosa Linn.),Udumbara (Ficus glomerata Roxb.),Plaksha (Ficus lacor Buch- Ham.) impregnated in Poly(lactic acid),and Poly Capro lactone as a polymer base. Study on animal models showed enhanced rate of wound contraction and drastic reduction in healing time than control group, which might be due to enhanced epithelialization. The animals treated with Bio degradable patch in which Compound Ayurvedic Drug was impregnated in Poly(lactic acid) as a polymer base showed significant (*p< 0.01) wound healing results when compared with control groups (dressing with Normal Saline). The treated wound after nine days itself exhibited marked dryness of wound margins with tissue regeneration. Groups treated with this patch showed better wound closure compared to control group. The cost effective factor and biodegradation of the prepared dermal wound healing patch was also found to be significant.

Keywords: Bio degradable patch, ficus species, excision wound model, wound healing.