Abstract

THE PROTECTIVE EFFECT OF ALOE VERA AGAINST RADIATION INDUCED DAMAGE TO INTESTINE OF SWISS ALBINO MICE

Priyanka Dadupanthi*

Abstract

The protection against radiation induced intestinal damage in Swiss Albino Mice by Aloe vera have been studied. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure (4.5 GY gamma-radiation). Mice were autopsied at 1 and 30 days after irradiation to evaluate the radiomodulatory effect in terms of protein, glycogen, cholesterol, LPO and GSH. Radiation treatment showed decrease in GSH content and an increase of LPO, protein, glycogen and cholesterol observed in control set animals, however the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO, protein, glycogen and cholesterol but values remained below normal. The result of present study suggests that Aloe vera has a radio protective effect due to their antioxidant and radical scavenging activity.

Keywords: Radiation, Radioprotection, Aloe vera, Antioxidant activity.