Abstract

ACUTE INTOXICATIONS WITH NEUROLEPTICS AND ANTIDEPRESSANTS

Kaloyan Georgiev*, Marieta Georgieva and Petko Marinov

Abstract

Objective: This retrospective study was conducted to follow out acute intoxications with neuroleptics and antidepressants in Northeastern Bulgaria (Varna region), to assess the frequency and proportion depending on total non-pharmacological and pharmacological poisoning. Methods: The objects of the study are 445 with acute neuroleptic and 148 patients with acute antidepressant intoxications treated in the Clinic of toxicology of the Military medical academy – Varna/Bulgaria. The study is retrospective and covers a period of 20 years (1991-2010). Results: Incidence of acute poisoning with neuroleptics is 7.5% of all drug poisoning and 2.5% of general poisoning, while in poisoning with antidepressants, these values are 2,5% and 0,9% respectively. Intoxications occur more commonly in women and the majority of poisonings are in people of working age. Conclusion: In recent years, there is a trend of an increase in the absolute number and the proportion of poisonings with neuroleptics and antidepressants. The lethality in these poisonings does not exceed 0.4-0, 7 percent.

Keywords: acute poisoning, intoxication, medicines, neuroleptics, antipsychotics, tricyclic antidepressants.