Abstract

IN-VITRO TRANSDERMAL DRUG DELIVERY ANALYSIS OF ZIMAD-E-KHARDAL: AN ANTI-EMETIC UNANI FORMULATION

Mohd Nauman Saleem* and Mohammad Idris

Abstract

Zimad-e-Khardal (ZK) is one of the Unani classical formulations used to inhibit nausea and vomiting. In the present study, the formulation based on Khardal (Brassica nigra) and Sirka (Vinegar) was prepared in the form of zimad (paste) to evaluate its transdermal permeation. The in-vitro permeation study was carried out using the Franz diffusion cell. The permeation study of ZK confirmed the presence of glycosides, carbohydrates, alkaloids and flavanoids as bioactive constituents in the receptor compartment. Also gradual increase with time in the qualitative parameters such as intensity of colour, amount of precipitates showed the permeation of bioactive agents from the designed formulation. The quantitative analysis was also done by using UV-Visible Spectrophotometer at 316 nm, and the collected samples were analyzed for concentration. The observations and result led to the scientific basis of transdermal delivery of ZK as well as validated its claim as a transdermal anti-emetic Unani formulation.

Keywords: Unani system, transdermal delivery, Zimad-e-Khardal, antiemetic Unani formulation.