Abstract

EVALUATION OF WOUND HEALING ACTIVITY OF POLYHERBAL FORMULATION

Ali Mohammad Sultan*, Chourasia Ravindra, Mohd. Shafi Dar, Mohd Jalaluddin,

Abstract

Objective: The present study describes the evaluation of wound healing activity of Polyherbal formulation of Calendula officinalis and ixora chinensis leaves extracts. Methods: The Phytochemical investigation, antioxidant activity of Calendula Officinalis and Ixora chinensis extracts was determined by using the DPPH free radical scavenging assay. The animals were randomly divided into 5 groups and each group containing 6 animals. The treatments of each gel (500 mg/rats) were applied topically once a day. Group I: Control group. Group II: Test group treated with Calendula Officinalis gel. (Formulation I) Group III: Test group treated with Ixora chinensis gel. (Formulation II), Group IV: Test group treated with (Calendula Officinalis and Ixora chinensis gel) (Formulation III), Group V: Gentamicin gel (Reference Standard Marketed Preparation). Results: As a result of this study it was found that the extracts of Calendula Officinalis and Ixora chinensis revealed wound healing activity. Conclusion: In present study it is concluded that wound healing potential of polyherbal gel is better than individual gel i.e. Calendula Officinalis and Ixora chinensis gel.

Keywords: Calendula Officinalis, Ixora chinensis, Wound Healing, Polyherbal Formulation.