Abstract

COUPLING REACTIONS OF ARYLDIAZONIUM SALT. PART-XIII: CINNAOLINE PRECURSORS USING CHEMOSELECTIVE CONDENSATION OF SUBSTITUTED DIAZONIUM SALT WITH ACETYLACETONE

C. J. Patil*, A. N. Dhake, Anil H. Shinde, Chunilal Pawara, Balsing B. Valvi, Lalsing R. Vasave, Nandu R. Vasave, Kalpesh S. Salve

Abstract

The aryldiazonium salt, Ar-N2⊕ClΘ are highly reactive compounds. It was used as intermediate in different reactions. In this work we have synthesized the varied aryldiazonium salt and coupled with an Active Methylene Group (AMG) containing compound viz. Pentane-2,4-dione or Acetyl acetone(AA). The synthesized compounds were characterized using TLC, UV-Vis, FTIR and 1H NMR techniques to arrive at the designated structures of the products formed. The final products formed, C-1 to C-6, were potentially used as precursors for synthesis of cinnoline or derivatives thereof. These compounds were tested for the antibacterial activity showed moderate activity than ciprofloxacin.

Keywords: Aryldiazonium salt, Azo compound, active methylene group, antibacterial activity.