Abstract

DEVELOPMENT OF PHYSICOCHEMICAL PARAMETERS AND PROBABLE CHEMICAL REACTION MECHANISM IN THE PREPARATION OF SHANKHADRAVAKA

Vikas Mishra*, Ashish Kumar, Puneeth Raj R. M., Sakhitha K. S., Reetesh Ramanai, Anupam Srivastava

Abstract

Introduction: Shankhadravaka is a classical Ayurvedic formulation prepared through distillation and traditionally used in the management of gastrointestinal disorders such as Annadrava Shoola (gastritis) and Udara Shoola (abdominal colic). Despite its therapeutic significance, standard physicochemical parameters and a validated analytical profile for this formulation remain insufficiently documented. This study was undertaken to develop physicochemical parameters, document pharmaceutical procedures, and propose a probable chemical reaction mechanism involved in the preparation of Shankhadravaka. Methods: Authenticated raw materials were procured from a GMP-certified pharmacy and verified by experts at the National Institute of Ayurveda, Jaipur. Classical Shodhana (purification) procedures were performed on each ingredient, and observations were recorded. Shankhadravakawas then prepared using traditional distillation apparatus, and organoleptic as well as physicochemical analyses—including pH, specific gravity, refractive index and total solid content—were carried out. The probable chemical mechanism was deduced based on observed results, classical Ayurvedic descriptions, and modern chemical interpretations. Results: During purification, significant weight reduction in Shankha confirmed effective impurity removal. The distillation yielded 12.5 ml (11.90%) of Shankhadravaka in 3 hours. Organoleptic examination revealed a sharp, ammonia-like odor, saline taste, and light yellow appearance. The physicochemical parameters obtained were: pH 9.72, specific gravity 1.1215 refractive index 1.3903and total solid content 1.3805%. The proposed chemical mechanism indicated the liberation of ammonia gas via interaction of Ammonium Chloride with alkaline carbonates, which subsequently dissolved in water vapor to form Ammonium Hydroxide (NH₄OH) in the distillate. Conclusion: The study substantiates the classical Shodhana and distillation practices described in Ayurvedic texts through modern analytical parameters. The physicochemical properties confirm the alkaline and stable nature of Shankhadravaka, supporting its traditional applications. The proposed reaction mechanism provides a scientific rationale for its therapeutic properties. These findings contribute to establishing quality control standards and analytical benchmarks for Shankhadravaka and similar distillate preparations in Ayurveda.

Keywords: Shankhadravaka, Ayurvedic distillation, physicochemical analysis, ammonia liberation, ammonium hydroxide, classical pharmaceutical validation.