Abstract

ANTIDIABETIC PROPERTIES OF GYMNEMA SYLVESTRE: AN INTEGRATIVE EVALUATION OF PHARMACOLOGICAL ACTIONS

Sanskruti Vittal Thorat*, Vaishanvi Dipak Sarode, Tanmay Bhagwan Aher, Kavita Daware

Abstract

Gymnema sylvestre has been part of Ayurvedic medicine for centuries, but now it’s grabbing the spotlight in scientific circles, especially when it comes to managing diabetes naturally. In this project, I’m digging into what’s inside the plant, how it actually works in the body, and why it matters for people with diabetes. Honestly, what stands out most are the powerful compounds packed into its leaves—gymnemic acids, gurmarin, and saponins. These aren’t just chemical names; they’re the real reason Gymnema can help lower blood sugar. They mess with how we taste sweetness, help the body make more insulin, nudge the pancreas to heal itself, and get muscles to soak up more glucose from the blood. But that’s not all. Gymnema slows down how quickly the gut absorbs sugar and helps keep cholesterol and other blood fats in check. That’s huge for anyone dealing with metabolic syndrome or diabetes. So, what do we see when people actually start taking it? Both animal and human studies show lower fasting blood sugar, better HbA1c levels, and improved insulin sensitivity. Pretty encouraging, right? Still, there’s a catch. The studies use all sorts of extracts, dosages, and ways of measuring results, so it’s tough to line everything up and compare. We need stronger, more standardized trials to really figure out how well it works and how safe it is over the long haul. Bottom line: Gymnema sylvestre looks like a promising natural option for people managing diabetes alongside other treatments. But until we get more solid research, we can’t say for sure how best to use it or how safe it is in the long run.

Keywords: Gymnema sylvestre, gymnemic acids, gurmarin, diabetes mellitus, glucose homeostasis, β-cell regeneration, herbal pharmacology, insulin secretion.