Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF GUDUCHI-MUSTADI KWATHA (YAVAKUTA)- AN AYURVEDIC HERBAL FORMULATION FOR VANDHYATVA (FEMALE INFERTILITY) DUE TO ANOVULATORY FACTOR ASSOCIATED WITH OBESITY

Alifeeya Vaghela*, Shilpa B. Donga, Harisha C. R.

Abstract

Background: Infertility is a widespread problem affecting individuals, families, and communities. Obesity has a wellestablished association with impaired reproductive function, with rising BMI linked to higher rates of menstrual irregularities and anovulation. Obese women show altered neuro-regulation of the hypothalamic-pituitary-ovarian axis, leading to disturbed ovulation and reduced fertility. Since anovulation accounts for about 40% of female infertility, a significant proportion is directly or indirectly related to obesity, along with lifestyle, medical, and environmental factors. Here, Guduchi-Mustadi Kashaya is mentioned by Acharya Charaka as a drug for the management of Atisthaulya was selected for the management of obesity. So, for initialization of standardization and assurance of the quality of herbal compounds, pharmacognostical and pharmaceutical analysis should be done. Methods: Guduchi-Mustadi Kwatha Yavakuta was subjected to microscopic evaluation for pharmacognostical and physicochemical analysis, such as loss on drying, total ash, water soluble extract, alcohol soluble extract and pH value. Results: Pharmacognostical study showed the presence of certain identifying characters of all the ingredients of Guduchi-Mustadi Kwatha Yavakuta like Guduchi, Musta and Triphala. As per the preliminary physiochemical analysis, loss on drying percentage of the Guduchi-Mustadi Kwatha Yavakuta was 8.58% w/w, pH value was 6, total ash value was 3.67 % w/w, water soluble extractive was 41.91%w/w and methanol soluble extractive was 42.57%w/w. Conclusions: Pharmacognostical and physico-chemical observations revealed the specific characteristics of all active constituents of Guduchi-Mustadi Kwatha Yavakuta confirmed the purity and genuineness of the drug.

Keywords: Guduchi-Mustadi Kwatha Yavakuta, Atisthaulya, Pharmacognosy, Pharmaceutical analysis.