Abstract

“TEZEPELUMAB: A COMPREHENSIVE REVIEW OF ITS MECHANISM, CLINICAL USE, SAFETY, ADVERSE EFFECTS, AND THERAPEUTIC ROLE IN SEVERE ASTHMA”

Zoya Ahmad*, Dr. Md. Israruddin

Abstract

Tezepelumab is a fully human IgG2 monoclonal antibody produced using recombinant DNA technology in Chinese hamster ovary (CHO) cells. It was approved by the U.S. Food and Drug Administration (FDA) in 2021 as an add-on maintenance therapy for patients with severe, uncontrolled asthma. The therapeutic action of Tezepelumab is based on the inhibition of thymic stromal lymphopoietin (TSLP), an epithelial-derived cytokine that plays a central role in initiating and sustaining airway inflammation. By blocking TSLP, Tezepelumab helps reduce multiple downstream inflammatory pathways involved in asthma pathogenesis, irrespective of eosinophil levels or allergic status. The drug is administered via the subcutaneous route using pre-filled syringes, with a recommended dose of 210 mg once every four weeks. Clinical trials have demonstrated a significant reduction in annualized asthma exacerbation rates compared to placebo, along with improvements in lung function and overall disease control. These outcomes highlight Tezepelumab as an effective therapeutic option for patients who do not achieve adequate symptom control with standard inhaled therapies. This activity aims to enhance clinicians’ understanding of Tezepelumab by outlining its indications, mechanism of action, pharmacokinetic properties, dosing regimen, route of administration, and considerations for special populations such as pregnant women and patients with comorbid conditions. Additionally, it reviews the potential adverse effects, contraindications, drug interactions, warnings, and toxicity concerns associated with its use. By providing comprehensive, evidence-based information, this activity supports informed clinical decision-making and promotes the safe and effective use of Tezepelumab. It also equips the interprofessional healthcare team with the knowledge required to optimize patient outcomes, improve asthma management, and ensure appropriate monitoring during therapy.

Keywords: Tezepelumab, Thymic stromal lymphopoietin, Maintenance therapy, Uncontrolled asthma, Cytokine, Biologic therapy.