Abstract

COMPARATIVE STUDY OF MONOTHERAPY VERSUS COMBINATION THERAPY IN HYPERTENSION MANAGEMENT

D. Jothieswari*, Are Jayasri, Ankem Gayathri, Billupati Pavan, Achukatla Afroze Ali, Bogguru Manoj Kumar

Abstract

Background: Hypertension is a major global public health problem and a leading risk factor for cardiovascular morbidity and mortality. Patients do not achieve proper blood pressure control because they have access to effective antihypertensive medications. The treatment guidelines currently recommend healthcare providers to select between single-drug treatment and multiple-drug treatment based on three factors which include the patient's hypertension severity and their personal attributes and existing medical conditions. Objective: The study compares monotherapy and combination therapy to determine which treatment option provides better outcomes for hypertension treatment through blood pressure control and safety measures and treatment effectiveness. Methods: The researchers conducted this study to compare blood pressure control between two treatment methods which included monotherapy and combination antihypertensive therapy for their research. The researchers collected data about the patient population through assessment of their demographic information and initial blood pressure readings and their treatment methods and both their blood pressure reduction results and their success in reaching target blood pressure levels and their experience with adverse drug reactions. The researchers used statistical methods to examine the treatment group differences between the two study groups. Results: Combination therapy provided better blood pressure control results than monotherapy because more patients reached their target blood pressure goals. The group that used combination therapy experienced more substantial reductions in both systolic and diastolic blood pressure measurements. The combination therapy produced more side effects than standard treatment but the resulting side effects were mostly minor and could be treated. The monotherapy treatment method achieved successful results for patients who had mild cases of hypertension. Conclusion: Combination therapy is more effective than monotherapy in achieving optimal blood pressure control, particularly in patients with moderate to severe hypertension. However, monotherapy remains a suitable initial approach for selected patients with mild hypertension. Individualized treatment selection based on patient profile and disease severity is essential for effective hypertension management.

Keywords: Hypertension, monotherapy, combination therapy, blood pressure management, cardiovascular risk.