Abstract

“CONCEPTUAL AND COMPARATIVE CLINICAL STUDY OF EFFICACY OF MUSTADI KWATHA IN PANDU AND SHOTH IN THE PURVIEW OF”-“SANTARPANOUTHANAM APATARPANAM AUSHDHAM”

Dr. Kiran*, Dr. Devendra Singh Chahar

Abstract

The Ayurvedic principle of Santarpanothanam Apatarpanam Aushadham posits that diseases arising from over-nutrition (Santarpanotha Vyadhi) should be treated with depleting therapies (Apatarpana). Pandu (anemia) and Shoth (edema) are distinct clinical entities sharing this common etiological root, characterized by Agni impairment, Ama formation, and Srotorodha (channel obstruction). Mustadi Kwatha, a classical polyherbal formulation, is indicated for such conditions. Objective is to conduct a comprehensive clinical evaluation of Mustadi Kwatha‘s efficacy in Pandu and Shoth, correlating its therapeutic action with the core pathophysiology of Santarpanotha Vyadhi. An open, comparative clinical trial was conducted on 100 patients (50 with Pandu, 50 with Shoth). Both groups received Mustadi Kwatha (decoction of 25g coarse powder) at a dose of 1 Pala on an empty stomach for 60 days. Assessment utilized subjective symptom scoring and objective parameters (CBC, ESR, LFT, RFT). Statistical analysis was performed using Wilcoxon signed-rank and paired/unpaired ‗t‘ tests. Mustadi Kwatha effectively manages both Pandu and Shoth by acting on the shared pathophysiology of Santarpanotha Vyadhi. Its efficacy lies in correcting Agni, eliminating Ama, and clearing Srotas, thereby reducing systemic inflammation. The study robustly validates the classical principle of Apatarpana therapy for over-nutrition-related disorders, offering a rational treatment approach for anemia and edema associated with metabolic dysfunction.

Keywords: Pandu, Shoth, Anemia, Edema, Mustadi Kwatha, Santarpana, Apatarpana, Ayurveda.