Abstract

FROM TRADITION TO INNOVATION: A POLYHERBAL NASAL OIL FOR RAPID MIGRAINE MANAGEMENT

*Shruti Shingade, Divya Tambe

Abstract

Migraine is a chronic neurological disorder characterized by recurrent, severe headaches often accompanied by nausea, photophobia, and phonophobia. Conventional therapies, although effective, are associated with limitations such as adverse effects and variable efficacy, leading to increased interest in alternative treatments, particularly herbal formulations. In the present study, a polyherbal nasal oil was developed using Feverfew, Ginger, Peppermint, and Ashwagandha incorporated into a sesame oil base. These herbs are known for their analgesic, anti-inflammatory, and neuroprotective properties. The intranasal route was selected to enable rapid absorption through the highly vascularized nasal mucosa, facilitating direct delivery to the brain while bypassing gastrointestinal metabolism. This approach is inspired by the Ayurvedic Nasya therapy. The formulation was evaluated for physicochemical parameters, including pH, viscosity, clarity, and microbial safety, along with in vitro anti-inflammatory activity. Results indicated that the formulation is stable and exhibits potential therapeutic effects. Overall, the polyherbal nasal oil shows promise as a natural alternative for migraine management, though further in vivo and clinical studies are required.

Keywords: Migraine; Polyherbal formulation; Nasal drug delivery; Nasya therapy; Antiinflammatory activity; Neuroprotection.