Abstract

SYSTEMATIC REVIEW OF VALIDATED METHODS FOR THE COANALYSIS OF AMLODIPINE AND ATORVASTATIN

Nidhi Dobariya*, Khushi Joshi, Dr. Ketan Shah, Dr. Ashok Akabari

Abstract

Managing your cardiovascular health often involves a combination of medications that target different aspects of your heart’s well-being. Amlodipine is a calcium channel blocker primarily used to treat high blood pressure and prevent chest pain, known as angina. By relaxing and widening your blood vessels, it allows blood to flow more easily, which significantly reduces the long-term risk of heart attacks and strokes. It is a convenient treatment, typically taken just once a day as a tablet or liquid, though it works best when taken at the same time every day to maintain a steady level in your system. Working alongside blood pressure management is the need to control cholesterol, which is where Atorvastatin comes in. As a member of the statin family, it works by blocking a specific enzyme in the liver that the body uses to produce cholesterol. By lowering the amount of cholesterol in your blood, it helps prevent the fatty buildup in your arteries that leads to heart disease. To ensure these medications are both safe and effective, researchers utilize advanced laboratory techniques like UV-Visible Spectrophotometry and High-Performance Liquid Chromatography (HPLC). These methods allow scientists to precisely measure the concentration and purity of the drugs, ensuring that every dose is consistent and reliable for the patient.

Keywords: Amlodipine, Atorvastatin, UV-Vis Spectrophotometry, High-Performance Liquid Chromatography (HPLC).