Abstract

COMPARATIVE LITERARY, ANALYTICAL, PHARMACOLOGICAL AND CLINICALEVALUATION OF GLP-1 MANAGEMENT A POLYHERBAL FORMULATION FOR THE MANAGEMENT OF MEDOROG / OBESITY W.S.F OBESITY, MECHANISTIC INSIGHTS, AND THERAPEUTIC EFFICACY

*Dr. Ravi Raj M.D. Ayurveda, Dr. Naveen Aggarwal

Abstract

Understanding Medorog / Obesity w.s.f Obesity and Its Ayurvedic Perspective: Medorog / Obesity is a defined as the Vyadhi that is pertaining to the Medodhathu. Medodhathu is one among the Saptha dhathu and its imbalance Vridhi and Kshaya which can cause many diseases. In the Vedic period, various synonyms can be seen in the Vedic literatures like Rigveda and Adharvaveda. In the Samhitha period, the Brihathrayees are the classical text. The Charakacharya explained Sthaulya as one of the Vyadhi accused due to Medovridhi. He explained it in the Sutrasthana Ashtaunindhithiya adhyaya. In Susrutha Samhitha, the Medorog / Obesity, Sthoulya karana explained as Rasa nimitha. Ashtanga Samgraha, detailed Medorog / Obesity, as Sthoulya and the Karana for Sthoulya is given as Ama. In Ashtanga Hridaya Sutrasthana, Dwividhopakraminiya adhyaya, Medo roga is explained as Sthoulya and it comes under the Langhanarha. The treatment of Medorog / Obesity, is mainly the Amaharathwa, Dhatwagni Deepana, Srothosodana. The medicines having Deepana pachana srothosodana lekhana can be administered for those who are suffering from Medorog / Obesity. Internal as well external therapy also plays a vital role in managing Medorog / Obesity. Rasayana also plays remarkable role in treating Medo roga. In this review article, mainly focusing on the Medorog / Obesity, Nidana panchak, Chikitsa that can be administered in the treatment of Medorog / Obesity. Integrative Ayurvedic Management of Medorog w.s.f Obesity: Each participant in the study received a 825 mg Polyherbal Formulated Tablet for the management of Medorog / Obesity, taken twice daily—once before breakfast and once before dinner. Along with the herbal therapy, patients were also guided on personalized dietary adjustments and healthy lifestyle practices suited to their individual needs. Regular follow-ups were conducted every 7 days over a period of 60 days to monitor progress and make necessary adjustments. By the end of the first month, 60 patients began to experience noticeable improvements—such as reduced excessive hunger. This positive outcome continued to strengthen throughout the study, demonstrating that combining Ayurvedic herbal support with nutrition and lifestyle modification can be a powerful and effective approach to diabetes management. At the end of the trial, the use of 825mg mg Polyherbal Formulated GLP-1 Management Tablet resulted in a statistically significant improvement in Obesity by reducing weight (P < 0.005) and reducing hunger (P < 0.005), urge of excessing eating (P < 0.005). This finding highlights the potential of Ayurvedic, plant-based therapies as a safe, natural, and holistic way to support Medorog / Obesity — focusing not only on symptom control like excessive Hunger, excessive craving, Loss of Energy (fatigue) excessive Sleep and excessive sweating and also on restoring energy, strength, well being and balance within the body.

Keywords: .