Abstract

SYNTHESIS, SPECTRAL STUDIES AND PHYSICAL CHARACTERISATION OF SOME NOVEL MORPHOLINE DERIVATIVES

Dr. P. R. Logeshkumar*, Dr. S. K. Senthilkumar, S. Jeevitha, C. Kamalesh, Pa. Kamaliya, S. Kamalraj, M. Karthikeyan

Abstract

Novel morpholine derivatives are synthesized through multistep reactions often involving morpholine with alkyl halides, aldehydes, or acid chlorides to form Schiff bases, hydrazides, or cyclic analogues, yielding high-purity compounds confirmed via spectroscopic methods. Spectral studies typically include ¹H NMR, ¹³C NMR, FT-IR and mass spectrometry to assign structures, revealing characteristic morpholine ring protons around 2.4-4.0 ppm, carbonyl stretches at 1650-1700 cm⁻¹ and molecular ions matching calculated masses. Physical characterizations involve melting points (often 120-200°C for solids), elemental analysis (CHN), and solubility in polar solvents like DMSO or ethanol, with many showing biological potential like Antibacterial and analgesic activity.

Keywords: .