Abstract

POLYHERBAL GEL FOR MANAGEMENT OF RHEUMATOID ARTHRITIS

Tanisha Raut*, Janu Rathod, Sejal Potdar, Rohan Pawar, Ms. Ujwala Khedkar

Abstract

Rheumatoid arthritis is a chronic autoimmune inflammatory disorder associated with joint pain, swelling, stiffness, and reduced mobility. There is a need for safer substitutes because long-term usage of traditional anti-inflammatory medications may have negative side effects. The present study was aimed at the formulation and physicochemical evaluation of a novel polyherbal topical gel intended for anti-inflammatory and analgesic application. The formulation was developed using a Carbopol 940 gel base incorporating a polyherbal extract mixture of Caesalpinia bonduc, Vitex negundo and Rubia cordifolia. The prepared gel was evaluated for physical appearance, pH, viscosity, spreadability, homogeneity, skin irritation, and stability. The formulation exhibited acceptable physicochemical properties, skin-friendly pH, good spreadability, and no signs of irritation, indicating its suitability for topical application. The study supports the development of a stable and patient-acceptable olyherbal gel formulation based on documented pharmacological properties of the constituent ingredients.

Keywords: Anti-inflammatory, Gel formulation, Vitex negundo, Caesalpinia bonduc, Rubia cordifollia, Carbopol 940, Murraya koenigii.