Abstract

A REVIEW ON THE ROLE OF INFLAMMATION IN SKIN CANCER AND NEW TREATMENT APPROACHES

Het Patel*, Dr. Nidhi Chauhan, Ayush Mallik, Azba Patel, Manav Upadhyay, Yash Seth

Abstract

The rate of skin cancer has escalated rapidly over the past decade, affecting both melanoma and non-melanoma types. Skin cancers primarily consist of keratinocyte cancers, including cutaneous squamous cell carcinoma, basal cell carcinoma, and melanoma. This review highlights recent progress in skin cancer treatments. In addition to chemotherapy, options such as immunotherapy, targeted therapy, and photodynamic therapy (PDT) are available for skin cancer. Furthermore, the combination of PDT with chemotherapy, radiation, immunotherapy, and surgery is currently being explored. This review will focus on the pathophysiology of skin cancer and existing therapies utilized in the topical treatment of skin cancers, as well as introduce novel treatments that may offer benefits for these conditions.

Keywords: Skin cancer, Melanoma, Non-Melanoma skin cancer, Tumorigenesis, Inflammation, Inflammasomes, Immune cells, Treatment.