Abstract

EFFECT OF IVERMECTIN ON REPRODUCTION OF EWE

Sania A.I. Shaddad*, A.K. Muddathir**, I. B. Eltayeb***, O.Z. Baraka*,
A.E.D. Abdalla**** and A. Dinnar*****

Abstract

This work was carried out on healthy productive Sudanese desert sheep using Ivermection (1% Ivomec) at the therapeutic single dose of Icc/50 kg body weight (200 jig! kg body weight) on nonpregnant animals. Ewes were synchronized by the double synchronization technique using progesterone and prostaglandin F2a. The detection of oestrus cycle was realized through the physiological and Kunand ram methods. Ivemectin was administered in two sets of experiments, one day and 8 days before ovulation of the second oestrus cycle. Plasma samples were collected everyday on three consecutive oestrus cycles. Progesterone was assayed by RIA technique Clear elevation of the hormone levels were demonstrated when the concentration of the drug was at its maximum which was obtained when the drug was administered one day before ovulation. No effect was observed when the drug was administered at the hormone decline phase. Our studies demonstrated that Ivermectin improved the reproductive performance of ewes as ovulation occurred at maximum concentration of the drug.

Keywords: RIA technique, oestrus cycles, Ivemectin.