Abstract

NOVEL CARRIERS IN TOPICAL ANTIFUNGAL THERAPY OF MICONAZOLE

Gajanan S. Sanap*, Guru Prasad Mohanta, Ajay Kharche, Pankaj Khuspe and
Bharat Vidhate

Abstract

Fungal infections are amongst the most commonly encountered dermatological diseases in worldwide. The topical route is generally preferred due to the possible side effects of oral medication. Miconazole nitrate is an antifungal drug with a drawback of poor skinpenetration in the treatment of deep seated fungal skin infections. Currently, antifungal drugs are generally used as conventional cream and gel preparations in topical treatment. The efficiency of that treatment depends on the penetration of drugs through the target layers of the skin at the effective concentrations. A number of formulation strategies have been investigated for delivering antifungal compounds through targeted site of the skin. This review article focuses on the new alternative formulation approaches to improve skin penetration of antifungal drugs miconazole.

Keywords: Miconazole nitrate; Antifungal; Nanocarriers; Topical delivery; Skinpenetration; formulation; fungal infections.