Abstract

MICROWAVE ASSISTED SYNTHESIS OF INDOLE BASED 4- DIMETHYLAMINO-PHENYL-N-METHYL/PHENYL-PYRAZOLIDINE PYRAZOLE DERIVATIVES AND STUDY OF THEIR ANTIINFLAMMATORY ACTIVITY

Deepak Swarnkar*, Rakshit Ameta and Ritu Vyas

Abstract

In the present investigation, the microwave assisted synthesis of substituted indole based pyrazole rings has been reported and their anti-inflammatory activity was evaluated. Chalcones (3a-b) were synthesized by base catalyzed aldol condensation of pdimethylaminobenzaldehyde (1) with acetone or acetophenone (2a-b) in the presence of piperidine. 1H-indole-2-carbhydrazide (7a-e) was prepared by reaction of 1H-indole-2-carboxylic acid (4) and conc. H2SO4 under microwave exposure get ethyl indole-2-carboxylate ester (5). Then this compound (5) was allowed to react with corresponding hydrazines (6a-e) in ethanol containing a few drops of glacial acetic acid under microwave irradiation to obtain compound (7a-e). Chalcones (3a-b) were treated with 1H-indole-2-carbhydrazide (7a-e) to get target compounds (8a-j). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR and 1H NMR spectral data. The synthesized compounds have been screened for their anti-inflammatory activity.

Keywords: Chalcones, Indole, Pyrazole, Microwave irradiation, Anti-inflammatory activity.